Lactobacillus acidophilus NCFM

“NCFM - one of the most extensively studied strains of Lactobacillus acidophilus.”

Backed by over 370 published studies, including more than 80 human clinical studies.

Master Cleaner

Supports healthy digestion and regular bowel movements.

Clinically evaluated for probiotic properties and human safety.

Found In

Dutch Mill DR-1

Lactose Free Probiotic Drinking Yogurt From Dutch Mill Research

Health Benefits of

Lactobacillus acidophilus NCFM

Digestive Health

Supports healthy digestion.¹
Helps relieve bloating and gas.¹
Helps relieve abdominal discomfort and supports digestive comfort in adults.²⁻³
Helps restore a balanced gut microbiome.⁴
Supports the growth of beneficial probiotic bacteria in the gastrointestinal tract.⁵⁻⁷
Supports gastrointestinal (GI) health and overall well being.⁸⁻⁹

Immune Health

Supports immune function in children.¹⁰
Promotes the growth of Lactobacilli and Bifidobacterium in the gut, helping support immune function.¹¹

Metabolic Health

Helps maintain healthy blood cholesterol levels.¹²
Supports fat and glucose metabolism in individuals at high risk of metabolic syndrome.¹³
Supports healthy insulin sensitivity.¹⁴

van Zanten G et al. Randomised, Placebo-Controlled Investigation of the Impact of Probiotic Consumption on Gut Microbiota Diversity and the Faecal Metabolome in Seniors. 2024 Apr 15;12(4):796. https://pubmed.ncbi.nlm.nih.gov/38674741/ 
Ringel-Kulka T et al. Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional bowel disorders: a double-blind study. J Clin Gastroenterol. 2011 Jul;45(6):518-25. https://pubmed.ncbi.nlm.nih.gov/21436726/ 
Ringel-Kulka T et al. Lactobacillus acidophilus NCFM affects colonic mucosal opioid receptor expression in patients with functional abdominal pain - a randomised clinical study. Aliment Pharmacol Ther. 2014 Jul;40(2):200-7. https://pubmed.ncbi.nlm.nih.gov/24853043/ 
Ouwehand AC et al. Lactobacillus acidophilus supplementation in human subjects and their resistance to enterotoxigenic Escherichia coli infection. Br J Nutr. 2014 Feb;111(3):465-73. https://pubmed.ncbi.nlm.nih.gov/23930950/ 
Hymes J P et al. Functional Analysis of an S-Layer-Associated Fibronectin-Binding Protein in Lactobacillus acidophilus NCFM. Appl Environ Microbiol. 2016 Apr 18;82(9):2676-2685. https://pubmed.ncbi.nlm.nih.gov/26921419/ 
Kaplan H and Hutkins R W. Fermentation of fructooligosaccharides by lactic acid bacteria and bifidobacteria. Appl Environ Microbiol. 2000 Jun;66(6):2682-4. https://pubmed.ncbi.nlm.nih.gov/10831458/ 
Barrangou R et al. Functional and comparative genomic analyses of an operon involved in fructooligosaccharide utilization by Lactobacillus acidophilus. Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8957-62. https://pubmed.ncbi.nlm.nih.gov/12847288/ 
Leyer GJ et al. Probiotic effects on cold and influenza-like symptom incidence and duration in children. Pediatrics. 2009 Aug;124(2):e172-9. https://pubmed.ncbi.nlm.nih.gov/19651563/ 
Harris L, et al. An Open-label, Multicenter Study to Assess the Efficacy and Safety of a Novel Probiotic Blend in Patients With Functional Gastrointestinal Symptoms. J Clin Gastroenterol. 2022 May-Jun;56(5):444-451. https://pubmed.ncbi.nlm.nih.gov/34028393/ 
Paineau D et al. Effects of seven potential probiotic strains on specific immune responses in healthy adults: a double-blind, randomized, controlled trial. FEMS Immunol Med Microbiol. 2008 Jun;53(1):107-13. https://pubmed.ncbi.nlm.nih.gov/18422632/ 
Ouwehand AC et al. Specific probiotics alleviate allergic rhinitis during the birch pollen season. World J Gastroenterol. 2009 Jul 14;15(26):3261-8. https://pubmed.ncbi.nlm.nih.gov/19598302/ 
Khan F I et al. Lactobacillus acidophilus NCFM, Inulin, and Oat Bran Reduce TC and LDL-C in Adults with Hypercholesterolaemia. Borneo Journal of Medical Sciences 16 (2) May, 2022: 31 – 46. https://www.researchgate.net/publication/363812176_Lactobacillus_acidophilus_NCFM_Inulin_and_Oat_Bran_Reduce_TC_and_LDL-C_in_Adults_with_Hypercholesterolaemia 
Yu P et el. Effect of an oral probiotic formula on scalp and facial skin condition, glucose, and lipid metabolism. Funct FoodsHealth Dis.2022. 12(7): 394-409. https://www.ffhdj.com/index.php/ffhd/article/view/944 
Andreasen AS et al. Effects of Lactobacillus acidophilus NCFM on insulin sensitivity and the systemic inflammatory response in human subjects. Br J Nutr. 2010 Dec;104(12):1831-8.https://pubmed.ncbi.nlm.nih.gov/20815975/

van Zanten G et al. Randomised, Placebo-Controlled Investigation of the Impact of Probiotic Consumption on Gut Microbiota Diversity and the Faecal Metabolome in Seniors. 2024 Apr 15;12(4):796. https://pubmed.ncbi.nlm.nih.gov/38674741/ 
Ringel-Kulka T et al. Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional bowel disorders: a double-blind study. J Clin Gastroenterol. 2011 Jul;45(6):518-25. https://pubmed.ncbi.nlm.nih.gov/21436726/ 
Ringel-Kulka T et al. Lactobacillus acidophilus NCFM affects colonic mucosal opioid receptor expression in patients with functional abdominal pain - a randomised clinical study. Aliment Pharmacol Ther. 2014 Jul;40(2):200-7. https://pubmed.ncbi.nlm.nih.gov/24853043/ 
Ouwehand AC et al. Lactobacillus acidophilus supplementation in human subjects and their resistance to enterotoxigenic Escherichia coli infection. Br J Nutr. 2014 Feb;111(3):465-73. https://pubmed.ncbi.nlm.nih.gov/23930950/ 
Hymes J P et al. Functional Analysis of an S-Layer-Associated Fibronectin-Binding Protein in Lactobacillus acidophilus NCFM. Appl Environ Microbiol. 2016 Apr 18;82(9):2676-2685. https://pubmed.ncbi.nlm.nih.gov/26921419/ 
Kaplan H and Hutkins R W. Fermentation of fructooligosaccharides by lactic acid bacteria and bifidobacteria. Appl Environ Microbiol. 2000 Jun;66(6):2682-4. https://pubmed.ncbi.nlm.nih.gov/10831458/ 
Barrangou R et al. Functional and comparative genomic analyses of an operon involved in fructooligosaccharide utilization by Lactobacillus acidophilus. Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8957-62. https://pubmed.ncbi.nlm.nih.gov/12847288/ 
Leyer GJ et al. Probiotic effects on cold and influenza-like symptom incidence and duration in children. Pediatrics. 2009 Aug;124(2):e172-9. https://pubmed.ncbi.nlm.nih.gov/19651563/ 
Harris L, et al. An Open-label, Multicenter Study to Assess the Efficacy and Safety of a Novel Probiotic Blend in Patients With Functional Gastrointestinal Symptoms. J Clin Gastroenterol. 2022 May-Jun;56(5):444-451. https://pubmed.ncbi.nlm.nih.gov/34028393/ 
Paineau D et al. Effects of seven potential probiotic strains on specific immune responses in healthy adults: a double-blind, randomized, controlled trial. FEMS Immunol Med Microbiol. 2008 Jun;53(1):107-13. https://pubmed.ncbi.nlm.nih.gov/18422632/ 
Ouwehand AC et al. Specific probiotics alleviate allergic rhinitis during the birch pollen season. World J Gastroenterol. 2009 Jul 14;15(26):3261-8. https://pubmed.ncbi.nlm.nih.gov/19598302/ 
Khan F I et al. Lactobacillus acidophilus NCFM, Inulin, and Oat Bran Reduce TC and LDL-C in Adults with Hypercholesterolaemia. Borneo Journal of Medical Sciences 16 (2) May, 2022: 31 – 46. https://www.researchgate.net/publication/363812176_Lactobacillus_acidophilus_NCFM_Inulin_and_Oat_Bran_Reduce_TC_and_LDL-C_in_Adults_with_Hypercholesterolaemia 
Yu P et el. Effect of an oral probiotic formula on scalp and facial skin condition, glucose, and lipid metabolism. Funct FoodsHealth Dis.2022. 12(7): 394-409. https://www.ffhdj.com/index.php/ffhd/article/view/944 
Andreasen AS et al. Effects of Lactobacillus acidophilus NCFM on insulin sensitivity and the systemic inflammatory response in human subjects. Br J Nutr. 2010 Dec;104(12):1831-8.https://pubmed.ncbi.nlm.nih.gov/20815975/

Lactobacillus acidophilus NCFM